Molecular genetic determinants of arterial thrombosis in patients with thoracoabdominal malignant tumors

Background . Acute ischemic cerebral circulation disorder and myocardial infarction occupy one of the first places among causes postoperative mortality in patients with malignant tumors thoracoabdominal localization. The issue role molecular genetic factors cardiovascular risk development these complications has not been resolved at present. Objective To analyze effect polymorphisms hemostasis system genes on coronary artery thrombosis Materials methods study included 163 operated Oncological Department Surgical Methods Treatment No. 11 (Thoracic Oncology) N.N. Blokhin National Medical Research Center Oncology 2018-2019. Two groups consisted (n = 62) stroke 24) perioperative period or anamnesis. data a history both 4) were taken into account groups. control group 81) who had no severe concomitant pathology, including family history. A to determine was performed Laboratory Clinical Oncogenetics using reagents “Cardiogenetics Thrombophilia” (DNA Technology LLC, Russia; RU FSR 2010/08414 dated 11/22/2016). Results In localization have suffered infarction, comparison without statistically significant difference frequency carriage homozygous variants FGB (χ 2 8.18, p 0.005), ITGA2 9.48, 0.003), PAI-1 4.45, 0.035), heterozygous forms F5 4.0, 0.046), 14.72, <0.001), ITGB3 4.28, 0.039), as well total aberrations genes. an stroke, determined relative variant mutation F2 gene 6.881, 0.009), form 15.724, 3.861, 0.05), carrying mutations did obtain studied respect polymorphism carriers G/A F7 (coagulation factor VII) G/T F13 XIII) associated reduced thrombotic conditions. all 91.7 % cases, several procoagulant noted genotype stroke; diseases, this indicator 53 %, 39.61, <0.001; χ 11.685, <0.001, respectively). Conclusion Based results high thrombogenic risk, occurrence polymorphic markers G1691A, G(-455)A, C807T, T1565C, 4G(-675)5G revealed G20210A, T1565C compared cancer pathology. conducted make it possible identify oncological increased developing take additional measures prevent complications.